Tottenham have been paired with French side Rennesin Group G of the Europa Conference League. As well as the Ligue 1 team, Spurs will also have to contend with Eredivisie team Vitesse and Mura of Slovenia.
Spurs secured a place in the group stage of the competition after beating Pacos Ferreira 3-0 in the second leg of their qualifying tie on Thursday, reversing a 1-0 defeat to the Portuguese side in the first clash.
Serie A outfit Roma have been drawn in Group C withZorya Luhansk, CSKA Sofia and Norwegian team Bodo/Glimt.
Elsewhere, LASK, Maccabi Tel-Aviv, Alahskert and Helsinki are together in Group A, while Gent are matched with Serbian side Partizan, Flora of Estonia and Anorthosis Famagusta from Cyprus.