Tottenham travel to Crystal Palace on Sunday with Jose Mourinho's side aiming to extend their unbeaten run in the Premier League to 11 matches.
However, the Eagles have only won two of their last nine home matches in the Englishtop-flight and bet365 offer them at 15/4 (4.75) to claim three points against their rivals from the north of the capital.
Spurs, meanwhile, can be backed at 7/10 (1.70) with the draw offered at 3/1 (4.00).Roy Hodgson will be unable to call upon the services of Wayne Hennessey, Nathan Ferguson, Martin Kelly and Conor Wickham, who all remain sidelined through injury.
The visitors are without Erik Lamela, while Serge Aurier is being assessed. Spurs made plenty of changes to the side for Thursday night's 2-0 Europa League win over Antwerp and the likes of Harry Kane, Son Heung-min and Hugo Lloris will all return.
Much was made of Tottenham's defensive resolve in last weekend's 2-0 derby win over Arsenal, yet Mourinho's men have shown they also have plenty of attacking capability at the other end of the pitch.
Spurs have scored two goals or more in 14 of their 21 competitive games this season, including seven of their last nine, and there could be some interest in backing them to continue that scoring run this weekend.